Modelo acústico de língua inglesa falada por portugueses

Trabalho de projecto de mestrado em Engenharia Informática, apresentado à Universidade de Lisboa, através da Faculdade de Ciências, 2007No contexto do reconhecimento robusto de fala baseado em modelos de Markov não observáveis (do inglês Hidden Markov Models - HMMs) este trabalho descreve algumas metodologias e experiências tendo em vista o reconhecimento de oradores estrangeiros. Quando falamos em Reconhecimento de Fala falamos obrigatoriamente em Modelos Acústicos também. Os modelos acústicos reflectem a maneira como pronunciamos/articulamos uma língua, modelando a sequência de sons emitidos aquando da fala. Essa modelação assenta em segmentos de fala mínimos, os fones, para os quais existe um conjunto de símbolos/alfabetos que representam a sua pronunciação. É no campo da fonética articulatória e acústica que se estuda a representação desses símbolos, sua articulação e pronunciação. Conseguimos descrever palavras analisando as unidades que as constituem, os fones. Um reconhecedor de fala interpreta o sinal de entrada, a fala, como uma sequência de símbolos codificados. Para isso, o sinal é fragmentado em observações de sensivelmente 10 milissegundos cada, reduzindo assim o factor de análise ao intervalo de tempo onde as características de um segmento de som não variam. Os modelos acústicos dão-nos uma noção sobre a probabilidade de uma determinada observação corresponder a uma determinada entidade. É, portanto, através de modelos sobre as entidades do vocabulário a reconhecer que é possível voltar a juntar esses fragmentos de som. Os modelos desenvolvidos neste trabalho são baseados em HMMs. Chamam-se assim por se fundamentarem nas cadeias de Markov (1856 - 1922): sequências de estados onde cada estado é condicionado pelo seu anterior. Localizando esta abordagem no nosso domínio, há que construir um conjunto de modelos - um para cada classe de sons a reconhecer - que serão treinados por dados de treino. Os dados são ficheiros áudio e respectivas transcrições (ao nível da palavra) de modo a que seja possível decompor essa transcrição em fones e alinhá-la a cada som do ficheiro áudio correspondente. Usando um modelo de estados, onde cada estado representa uma observação ou segmento de fala descrita, os dados vão-se reagrupando de maneira a criar modelos estatísticos, cada vez mais fidedignos, que consistam em representações das entidades da fala de uma determinada língua. O reconhecimento por parte de oradores estrangeiros com pronuncias diferentes da língua para qual o reconhecedor foi concebido, pode ser um grande problema para precisão de um reconhecedor. Esta variação pode ser ainda mais problemática que a variação dialectal de uma determinada língua, isto porque depende do conhecimento que cada orador têm relativamente à língua estrangeira. Usando para uma pequena quantidade áudio de oradores estrangeiros para o treino de novos modelos acústicos, foram efectuadas diversas experiências usando corpora de Portugueses a falar Inglês, de Português Europeu e de Inglês. Inicialmente foi explorado o comportamento, separadamente, dos modelos de Ingleses nativos e Portugueses nativos, quando testados com os corpora de teste (teste com nativos e teste com não nativos). De seguida foi treinado um outro modelo usando em simultâneo como corpus de treino, o áudio de Portugueses a falar Inglês e o de Ingleses nativos. Uma outra experiência levada a cabo teve em conta o uso de técnicas de adaptação, tal como a técnica MLLR, do inglês Maximum Likelihood Linear Regression. Esta última permite a adaptação de uma determinada característica do orador, neste caso o sotaque estrangeiro, a um determinado modelo inicial. Com uma pequena quantidade de dados representando a característica que se quer modelar, esta técnica calcula um conjunto de transformações que serão aplicadas ao modelo que se quer adaptar. Foi também explorado o campo da modelação fonética onde estudou-se como é que o orador estrangeiro pronuncia a língua estrangeira, neste caso um Português a falar Inglês. Este estudo foi feito com a ajuda de um linguista, o qual definiu um conjunto de fones, resultado do mapeamento do inventário de fones do Inglês para o Português, que representam o Inglês falado por Portugueses de um determinado grupo de prestígio. Dada a grande variabilidade de pronúncias teve de se definir este grupo tendo em conta o nível de literacia dos oradores. Este estudo foi posteriormente usado na criação de um novo modelo treinado com os corpora de Portugueses a falar Inglês e de Portugueses nativos. Desta forma representamos um reconhecedor de Português nativo onde o reconhecimento de termos ingleses é possível. Tendo em conta a temática do reconhecimento de fala este projecto focou também a recolha de corpora para português europeu e a compilação de um léxico de Português europeu. Na área de aquisição de corpora o autor esteve envolvido na extracção e preparação dos dados de fala telefónica, para posterior treino de novos modelos acústicos de português europeu. Para compilação do léxico de português europeu usou-se um método incremental semi-automático. Este método consistiu em gerar automaticamente a pronunciação de grupos de 10 mil palavras, sendo cada grupo revisto e corrigido por um linguista. Cada grupo de palavras revistas era posteriormente usado para melhorar as regras de geração automática de pronunciações.The tremendous growth of technology has increased the need of integration of spoken language technologies into our daily applications, providing an easy and natural access to information. These applications are of different nature with different user’s interfaces. Besides voice enabled Internet portals or tourist information systems, automatic speech recognition systems can be used in home user’s experiences where TV and other appliances could be voice controlled, discarding keyboards or mouse interfaces, or in mobile phones and palm-sized computers for a hands-free and eyes-free manipulation. The development of these systems causes several known difficulties. One of them concerns the recognizer accuracy on dealing with non-native speakers with different phonetic pronunciations of a given language. The non-native accent can be more problematic than a dialect variation on the language. This mismatch depends on the individual speaking proficiency and speaker’s mother tongue. Consequently, when the speaker’s native language is not the same as the one that was used to train the recognizer, there is a considerable loss in recognition performance. In this thesis, we examine the problem of non-native speech in a speaker-independent and large-vocabulary recognizer in which a small amount of non-native data was used for training. Several experiments were performed using Hidden Markov models, trained with speech corpora containing European Portuguese native speakers, English native speakers and English spoken by European Portuguese native speakers. Initially it was explored the behaviour of an English native model and non-native English speakers’ model. Then using different corpus weights for the English native speakers and English spoken by Portuguese speakers it was trained a model as a pool of accents. Through adaptation techniques it was used the Maximum Likelihood Linear Regression method. It was also explored how European Portuguese speakers pronounce English language studying the correspondences between the phone sets of the foreign and target languages. The result was a new phone set, consequence of the mapping between the English and the Portuguese phone sets. Then a new model was trained with English Spoken by Portuguese speakers’ data and Portuguese native data. Concerning the speech recognition subject this work has other two purposes: collecting Portuguese corpora and supporting the compilation of a Portuguese lexicon, adopting some methods and algorithms to generate automatic phonetic pronunciations. The collected corpora was processed in order to train acoustic models to be used in the Exchange 2007 domain, namely in Outlook Voice Access

Manual de boas práticas e sustentabilidade no turismo

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Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)